Novak Djokovic defeated Kevin Anderson in the final, 6–2, 6–2, 7–6(7–3) to win the gentlemen's singles tennis title at the 2018 Wimbledon Championships.

Former champion and local favourite Andy Murray announced on the day before the tournament began that he was pulling out because he was not fully recovered from hip surgery.

3 seed Marin Čilić went out in the second round of the tournament, defeated by Guido Pella of Argentina.

López was defeated in the second round by no 5 seed Juan Martín del Potro.

[9] Anderson became the first man representing South Africa to reach the Wimbledon men's singles final since Brian Norton in 1921 (South African-born Kevin Curren represented the United States when he was a finalist in 1985).