The club competed in Serie A, the Coppa Italia, and, for the first time ever following their third-place finish the previous season, in the UEFA Champions League.

Following an agreement reached with both Milan clubs, Atalanta played their Champions League home matches at San Siro.

[3] Amid the coronavirus pandemic in Italy, on March 25, the Associated Press dubbed the Champions League match between Atalanta and Spanish club Valencia at the San Siro in Milan on 19 February as "Game Zero".

[4] With Iličić, Muriel, and Zapata all scoring over 15 league goals, they became the first club to have three players strike at least 15 times in Serie A since Juventus achieved the feat 70 years prior in 1951–52.

[5] On 21 July 2020, Atalanta reached 95 goals in Serie A, the highest by any side in a single season for more than 60 years.