Colón started their pre-season campaign with defeat at the hands of Gimnasia y Esgrima (J) of Primera B Nacional on 22 June 2019, with Diego López notching the only goal of the game.
[2] They played one further fixture with Gimnasia that day, running out 4–0 winners at the Estadio Padre Ernesto Martearena; Mateo Hernández notched a brace.
[3] Two new signings were confirmed in the week commencing 24 June, as Gastón Díaz joined from Vélez Sarsfield while Rodrigo Aliendro made a move from Atlético Tucumán.
[6][7] A third and fourth exhibition match was played on 29 June, as Colón held Newell's Old Boys to a draw in game one before winning the second thanks to Nicolás Leguizamón.
[13] Colón, on 11 July, opened their competitive schedule with defeat after losing to league rivals Argentinos Juniors in the first leg of a Copa Sudamericana round of sixteen tie, following a strike from Matías Romero after thirty-eight minutes on home soil.
[28] Colón advanced to the Copa Sudamericana semi-finals on 15 August, as they struck four goals at the Estadio Brigadier General Estanislao López to overturn the first leg deficit against Venezuela's Zulia; who finished the contest with nine men.
A three-team friendly tournament, named Cementerio de los Elefantes, was planned to take place at the end of June with Independiente and San Lorenzo but was later scrapped.
[81][82] On 14 June 2019, Colón announced a pre-season training camp would take place in Salta, with the club arranging a friendly fixtures at the Estadio 23 de Agosto against Gimnasia y Esgrima (J) of Primera B Nacional.