[3] América were the defending champions after they defeated Juárez 0–1 in the Clausura 2019 final.
[5] However, the Leagues Cup was canceled due to the COVID-19 pandemic in North America.
This has also been the latest edition of the tournament, as it suspended play due to the COVID-19 pandemic and the Mexican Football Federation giving preference for matches for the Mexico National Football Team towards the 2022 FIFA World Cup.
This tournament featured the 15 clubs from Liga MX who did not participate in the 2020 CONCACAF Champions League (América, Cruz Azul, León, and UANL).
Clubs in Pot 1 were drawn to be the seed of each group according to the order of their drawing.
[8] Pot 3 also contains recently promoted Atlético San Luis.
[14][15] Monterrey won 2–1 on aggregate Players sorted first by goals scored, then by last name.