The Hoyas, led by third-year head coach Patrick Ewing, played their home games at the Capital One Arena in Washington, D.C., as members of the Big East Conference.

Also arriving were guard Terrell Allen, a graduate transfer from Central Florida who had spent a season at Drexel before two years at UCF, and junior small forward Galen Alexander; recruited out of high school, Alexander had signed with LSU, was dismissed from the team there without ever playing a game amid allegations that he had fired paintballs at other students, and subsequently spent two years at Jones County Junior College.

[3] Five freshmen — centers Timothy Ighoefe, Qudus Wahab, and Malcolm Wilson, forward Myron Gardner, and recruited walk-on Chuma Azinge,[4] a guard — rounded out the team.

There were nine returning players from the previous season including four of that year's five starters,[5] freshman standouts Akinjo, LeBlanc, and McClung among them,[6] as well as Yurtseven, replacing the departed Govan[6] and Alexander.

[6] The Hoyas opened the season on November 6 at Capital One Arena by shooting only 30 percent from the field against Mount St. Mary's in the first half, falling behind 37–25 at halftime.

[24] The Hoyas then traveled to Madison Square Garden in New York City to begin the bracketed portion of the Empire Classic with a meeting in the semifinals with their first ranked opponent of the season, No.

[25] The crowd — which included former Georgetown and National Basketball Association great Alonzo Mourning[25] and Brooklyn Nets centers Jarrett Allen and Kevin Durant[25] — welcomed former New York Knicks star Ewing back to Madison Square Garden, his home court for most of his professional playing career, by chanting its support both for Georgetown and for Ewing,[25] who told the press post-game, "It felt like back in my Knick days.

[25] McClung scored 19 points,[25][27] Jamorko Pickett added 15,[25][27] James Akinjo finished with 14,[25][27] and Yurtseven — whose double-double streak finally ended[27] — had 10.

[43][44] However, the teams continued the series ans, a week after defeating SMU and the day after Alexander and Gardner departed, Georgetown concluded the non-conference portion of their season with a four-game homestand at Capital One Arena that opened against Syracuse.

[42] Displeased with the officiating, the Syracuse bench was assessed a technical foul when it protested a blocking foul called against the Orange midway through the first half,[42] and late in the second half injured Syracuse sophomore guard Jalen Carey was ejected from the game for tripping Terrell Allen while Allen was playing near the Orange's bench.

[53] However, the non-conference portion of the season ended amid concerns that Georgetown's lack of depth after December's scandals and transfers would hurt the team in Big East play.

[57] With just over three minutes to play, McClung — who had returned to action after missing the conference opener — and Pirates redshirt senior guard Quincy McKnight exchanged words, leading to a pushing and shoving match among several players that resulted in the officials assessing technical fouls on McClung and McKnight and ejecting from the game four Hoyas and two Pirates who had left their respective benches to join the fracas.

[61] Bey finished shooting 10-for-15 (66.7 percent) from the field — including 8-for-10 from three-point range — and sinking five free throws to score a career-high 33 points.

[61] Qudus Wahab came off the bench to lead the Hoyas with 13 points,[61][62] while Jamorko Pickett finished with 12 and Ömer Yurtseven and Terrell Allen each scored 10.

[63] Mac McClung scored 19 points,[63][65] Jagan Mosely — who played the entire 40 minutes of the game[63] — finished with 13,[63][65] and Jahvon Blair came off the bench to add 12.

[67] In the Xavier game, cold early shooting doomed the Hoyas: Georgetown started out shooting 3-for-16 (18.8 percent) from the field while Xavier built an early 23–8 lead,[68] managed only 23 first-half points against the Musketeers,[68] tying the season low in a half they had set against Providence on December 31,[68] and scored fewer than 60 points for the first time all season.

Before the first game of February Georgetown's top scorer, Mac McClung, was reported to have suffered a foot injury during practice;[73] after the season, his ailment was revealed as plantar fasciitis.

In the St. John's game, the Hoyas broke their three-game losing streak and completed a regular-season sweep of the Red Storm, overcoming a 17-point deficit with 16 minutes to play to eke out a 73–72 victory.

12 Seton Hall opened the game with a 16–0 scoring run during which the Pirates made all four three-point shots they attempted,[53] led 42–32 at halftime,[53] and won for the ninth time in the last 11 meetings between the schools,[53] Seton Hall senior guard Myles Powell scored 34 points on 12–for–24 shooting from the field,[53][79] raising his per-game average against Georgetown to 29 points over five games.

[84] With Georgetown clinging to a 61–60 lead with 3:46 left to play, Allen sank a jumper in the paint, then followed it with a three-pointer with 1:28 remaining to put the Hoyas ahead 66–60.

Georgetown led at halftime, but the Friars shot 60 percent in the second half and came from behind to win by 10 points, sweeping the Hoyas in the season series.

[85] Mac McClung, still nursing his injured foot, made his first appearance since January 28 and his last of the season, playing only eight minutes, scoring two points and grabbing a rebound.

On Senior Day at Capital One Arena, Villanova opened the game with a 14–0 scoring run,[97] and led by as many as 17 points during the first half on 60 percent shooting from the field and 8–for–13 from three-point range,[97] taking a 39–30 lead into halftime.

[97] After a video review, officials confirmed a goaltending call on Wahab, making the basket count, and Samuels then sank his free throw for a three-point play that gave the Wildcats a 70–69 lead.

[97][99] Georgetown clearly missed McClung and Yurtseven, who were averaging a combined 30 points a game when they succumbed to injury,[95] and concluded its regular season with a six-game losing streak and a record of 15–16 overall.

[107] Plagued by roster problems which began with December's scandals and transfers and were compounded in February and March by injuries to its two top scorers, the 2019–2020 Georgetown team had a tumultuous, frustrating, and disappointing season.

[116] Muresan, a four-year walk-on, finished with appearances in 31 games during his college career, playing 110 minutes, scoring 13 points, and grabbing 12 rebounds.

[134] Even before McClung announced his exploration of NBA draft prospects in late March, however, at least some observers felt that by the time it ended on a seven-game losing streak, with a record little better than that of John Thompson III's final year as head coach in the 2016-2017 season and with a depleted roster, the 2019–2020 season instead represented a step backward for the program, with no real progress toward a return to the NCAA Tournament and national prominence during Ewing's three years as head coach.

[103] With three open scholarship positions left to fill even before the loss of McClung opened up a fourth,[135] and under great pressure to find both top talent and players whose character issues would not lead to a repeat of the scandals of December,[135] Ewing and his staff had begun an aggressive recruiting effort by mid-March, reportedly exerting a greater effort to assess the character and "coachability" of players before recruiting them.

[134] The program and its fans hoped that the loss of Mac McClung was the final step in moving on from Ewing's failure to retain any of the recruiting class of 2018.