The Bison, led by first-year head coach Kenny Blakeney, played their home games at Burr Gymnasium in Washington, D.C. as members of the Mid-Eastern Athletic Conference (MEAC).

In the MEAC tournament, they defeated Bethune–Cookman in the quarterfinals,[1] before falling to Norfolk State in the semifinals.

[2] They were invited to the CBI, where they lost in the first round to Coastal Carolina.

[3] On March 27, 2019, it was announced that head coach Kevin Nickelberry had resigned, ending his nine-year tenure with the team.

[4] On May 6, it was announced that Columbia assistant Kenny Blakeney would be Howard's next head coach.