A total of 12 teams will contest the league, including 10 sides from the 2017–18 Liga Nacional and 2 promoted from the 2017–18 Primera División.
Deportivo Petapa and Chiantla were relegated to 2018–19 Primera División the previous season.
Comunicaciones drew the highest average home attendance in the Apertura.
Antigua GFC Coban Imperial CSD Comunicaciones Guastatoya Deportivo Iztapa Deportivo Malacateco (player released during the Apertura season) (player released between the Apertura and Clausura seasons) (player released during the Clausura season)
Santa Lucía Cotzumalguapa Sanarate Siquinalá Club Xelajú MC