The 2019–20 Quaid-e-Azam Trophy was a first-class domestic cricket competition that took place in Pakistan from 14 September to 31 December 2019.

[3] However, after the new domestic structure was announced by Pakistan Cricket Board (PCB), six newly formed regional teams played in the tournament.

[17] The PCB also considered splitting the tournament into two parts, to have a window for the domestic T20 competition and the draft for the 2020 Pakistan Super League.

[21] The PCB also updated the playing conditions for the tournament, including removing the mandatory coin toss and the possibility of extending the final by an extra day, if needed.

[26] In September 2019, Wahab Riaz took an indefinite break from red-ball cricket, therefore withdrawing himself from Southern Punjab's squad.