[2] On 11 June 2019, Rosario Central announced the signing of Ciro Rius; the right winger, who joined from Defensa y Justicia, would make his unofficial debut four days later as the club played their first friendly.
[7] A deal with Unión Santa Fe was reached, subject to personal terms and medicals, on 20 June for the transfers of Emanuel Brítez and Diego Zabala.
[9][10] Their next match was played on 22 June, as they beat Sportivo Las Parejas with Claudio Riaño, Fabián Rinaudo, Facundo Almada and Ortigoza goals.
[21][22] Rosario lost on penalties in an exhibition match at the Estadio Manuel Ferreira against Olimpia on 6 July.
[37][38] Rosario Central began their league campaign with a victory on the road against Atlético Tucumán on 29 July, with new signing Ciro Rius netting alongside Leonardo Gil.
[46] A goal versus Talleres from off-season signing Diego Zabala secured Rosario two wins from two in the Primera División on 3 August.
[48] Rosario met Argentino in friendly action again on 9 August, as they beat them by scoring twice, as they did on 15 June, in both games.
[52] Rosario made it four undefeated in the league on 24 August, after drawing at home to Patronato; Maximiliano Lovera scored for them.
[54][55] Rosario experienced their third tie in a row on 1 September after a 1–1 scoreline with Colón, though the result did extend their unbeaten streak to five matches.
Rosario Central's first pre-season fixture was revealed on 12 June 2019 against city rivals Argentino, set for 15 June, which was followed by the announcement of friendlies in Asunción, Paraguay with Paraguayan Primera División side Olimpia, set for 6 July, and Sol De Mayo; though the latter was later cancelled.