Sevilla competed in La Liga, the Copa del Rey and the UEFA Europa League, winning the latter for a record sixth time.

On 21 May 2018, Sevilla announced a new three-year kit supply contract with American sportswear giant Nike from 2018–2021.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

All La Liga teams, except the four participants in the Supercopa de España, entered in the first round.

Since the winners of the Copa del Rey, Valencia, also qualified for European competition based on league position, the spot awarded to the cup winners (Europa League group stage) was passed to the sixth-placed team.