The competition was won by Dunipace for the first time, beating Broomhill 3–1 in the final, which had been delayed due to the COVID-19 pandemic and took place almost two years after the first round matches.
Seven days after the draw Kinnoull joined the East of Scotland League following the withdrawal of Eyemouth, and were permitted to take-on their home tie against The Spartans.
Broomhill (BSC Glasgow at the time) received a bye in the first round before they began their campaign away to East of Scotland League Premier Division side Bo'ness United.
Fellow Lowland League club Gala Fairydean Rovers were next up, then Preston Athletic of the EOSFL First Division.
They won on penalties against eventual Lowland League champions Kelty Hearts shortly before the March 2020 lockdown.
Their semi-final took place after a delay of 14 months, away to Hill of Beath Hawthorn of the EOSFL Premier Division.