The European Handball Federation rearranged the Last 16 phase of the Women's Challenge Cup 2019–20 after the Turkish club Ardeşen GSK withdrew from the competition.

In order to harmonize the competition after the withdrawal of Ardeşen GSK, the EHF decided to award Aula Alimentos de Valladolid, as the best seeded team in the Women's Challenge Cup 2019–20 a place directly in the Quarterfinals.

[3] All draws were held at the European Handball Federation headquarters in Vienna, Austria.

[4][5] On 25 March, the EHF announced that no matches will be played before June due to the coronavirus pandemic.

[8] The European Handball Federation has decided 5 teams to proceed directly seeded for the Last 16 round.

The European Handball Federation rearranged the Last 16 phase of the Women's Challenge Cup 2019–20 after the Turkish club Ardeşen GSK withdrew from the competition.

In order to harmonize the competition after the withdrawal of Ardeşen GSK, the EHF decided to award Aula Alimentos de Valladolid, as the best seeded team in the Women's Challenge Cup 2019–20 a place directly in the Quarterfinals.

[12] The draw event was held at the EHF Office in Vienna on Tuesday 11 February 2020.