In the preseason ACC media poll, Boston College was predicted to finish in fifth in the Atlantic Division.

[4] Listed in the order that they were released Boston College's 2019 schedule began with their conference home opener against Virginia Tech on August 31.

In non-conference play, the Eagles played home games against Richmond of the Colonial Athletic Association and Kansas of the Big 12 Conference, and road games against Rutgers of the Big Ten Conference and Notre Dame, a football independent.

[9] The Kansas Jayhawks came into the game as a three touchdown underdog, but performances by quarterback Carter Stanley (238 yards passing) and running back Pooka Williams Jr. (121 yards rushing) combined with other efforts to give the Jayhawks their first road win against a "power 5" team in almost 11 years.

Kansas took the lead 28-24 at the half thanks to an 82 yard run with 40 seconds remaining before the break to set up a 3-yard score just two plays later.