The 2019 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as member of the Big Sky Conference during the 2019 NCAA Division I FCS football season.
Led by Tim Walsh in his 11th and final season as head coach, Cal Poly compiled an overall record of 3–8 with a mark of 2–6 in conference play, placing in a five-way tie for ninth in the Big Sky.
[1] The Big Sky released their preseason media and coaches' polls on July 15, 2019.
[2] The Mustangs did not have any players selected to the preseason all-Big Sky team.
[3] The game with Weber State, fellow Big Sky Conference member, on September 7 was considered a non-conference game and had no effect on the Big Sky standings.