The 22nd running of the women's Flèche wallonne was held on 24 April 2019.

The route featured seven categorized climbs, including two ascents of the Mur de Huy.

The finish line was on the top of the final ascent of the Mur.

[1] It was won for the fifth consecutive time by Anna van der Breggen.

[2] There were 7 categorised climbs: Twenty-four teams participated in the race.