Ashleigh Barty defeated Markéta Vondroušová in the final, 6–1, 6–3 to win the women's singles tennis title at the 2019 French Open.

Anisimova was the first tennis player born in the 21st century to reach the quarterfinals and semifinals of a major.

Osaka's streak of 16 consecutive wins at the majors was broken when she lost to Kateřina Siniaková in the third round.

For the first time since the 1978 Australian Open, none of the four semifinalists had previously reached a major singles final.

It was also the first major appearance of future Wimbledon champion Elena Rybakina, who entered the main draw as a qualifier and lost to Kateřina Siniaková in the first round.