A four-game preseason slate was initially announced, featuring matches against teams from Major League Soccer, the USL Championship, USL League One, and one collegiate program.

A fifth game, against Forward Madison FC, was later added to the schedule.

Indy will open at Lucas Oil Stadium on March 30, meeting expansion club Hartford Athletic for the first time.

The season will once again consist of 34 matches, with the Eleven playing home and away against each Eastern Conference opponent.

[5] As a member of the USL Championship, Indy Eleven will enter the tournament in the second round, to be played May 14–15, 2019.