Members of the Big 12 Conference during the 2019 NCAA Division I FBS football season, the Jayhawks played their home games at David Booth Kansas Memorial Stadium.

They also extended their streak of consecutive games lost to teams ranked in the AP poll to 38.

With a 48–24 win over Boston College, KU ended a 48-game road losing streak against power five conference teams.

On July 8, 2019, Kansas announced that 1st team All-Big 12 running back Pooka Williams Jr. will be suspended for the first game of the season against Indiana State as discipline for his arrest for domestic battery December 2018.

The Kansas Jayhawks came into the game as a three touchdown underdog, but performances by quarterback Carter Stanley (238 yards passing) and running back Pooka Williams (121 yards rushing) combined with other efforts to give the Jayhawks their first road win against a "power 5" team in almost 11 years.

Kansas took the lead 28–24 at the half thanks to an 82-yard run with 40 seconds remaining before the break to set up a 3-yard score just two plays later.

[6] Kansas started conference play having just rolled off a win against Boston College, but West Virginia was expected to take advantage of observing the Jayhawks offensive performance the prior week.

It also appeared that KU kicker Liam Jones faked an injury after a field goal to make way for Jacob Borcila to "replace" him at the next kickoff to execute an onside kick—which they recovered but then lost due to a penalty.

[8] Texas Christian scored 21 points in the first quarter against Kansas and led 38–0 at halftime, with Max Duggan making his second consecutive start at quarterback.

However, Alex Delton still was on record as a team captain and he saw play time in the second half.

Quarterback Carter Stanley finished 12–29 in passing with 84 yards, but the Jayhawks managed to score in the fourth quarter to avoid being shut out.

With 1:11 left to play when Texas took over and put together an offensive drive that ended with a game-winning field goal for the Longhorns.

[12] Texas Tech controlled the game early, racing to a 17–0 lead in the second quarter before Kansas quarterback Carter Stanley scored 2 touchdowns, 1 rushing and 1 passing, in the final 5 minutes of the half to go into halftime down 17–14.

Texas Tech would similarly dominate the early part of the second half, scoring 10 unanswered points, before being answered with two long touchdown passes by Stanley to tie the game at 27.

Both teams come in after solid growth and improvement through the season and enter the game excited for their rivalry.