The 2019 La Drôme Classic was the 6th edition of the La Drôme Classic cycle race.

It was held on 3 March 2019 as a category 1.1 race on the 2019 UCI Europe Tour.

The race started and finished in Livron-sur-Drôme.

The race was won by French rider Alexis Vuillermoz of AG2R La Mondiale, ahead of fellow French riders Valentin Madouas of Groupama–FDJ and Warren Barguil of Arkéa–Samsic.

[1] Nineteen teams of up to seven riders were invited to the race.