Coming off a Peach Bowl appearance in 2018, Michigan began the year as slight favorites to win the Big Ten Conference, and were ranked seventh in the preseason AP Poll.

The offense was led by senior quarterback Shea Patterson, who became just the third Wolverine passer to ever eclipse the 3,000 yards passing mark.

[3][4] Assistant head coach and passing game coordinator Pep Hamilton left the team in February.

[5] The team released a statement in February 2019 that running back Chris Evans, who was set to be the Wolverines' leading returning rusher, was no longer with the program.

For the 2019 poll, Michigan was voted as the favorite to win both the East Division and the Big Ten Championship Game.

The radio announcers are Jim Brandstatter with play-by-play, Dan Dierdorf with color commentary, and Doug Karsch with sideline reports.

[30] Middle Tennessee opened the scoring in the first quarter with an 18-yard touchdown run from Asher O'Hara, to take its first and only lead of the game.

Michigan responded with a 34-yard field goal by Jake Moody, and a 36-yard touchdown pass from Shea Patterson to Tarik Black to take the lead.

Middle Tennessee responded with a two-yard touchdown pass from O'Hara to Jarrin Pierce, which made the score 27–14 in favor of Michigan at half-time.

Early in the second half, Army found itself in the red zone with an opportunity to take a two-score lead, however Hopkins threw an interception to Lavert Hill.

On Army's ensuing possession, Hopkins was sacked by Kwity Paye and Aidan Hutchinson, and the ball was fumbled and recovered by Josh Uche to seal the victory for the Wolverines.

[32] After playing Army and having a bye week, Michigan traveled to Madison to face the Wisconsin Badgers in its Big Ten Conference opener.

[45] Michigan scored ten points in the first quarter on a 28-yard field goal by Jake Moody and a two-yard touchdown run from Zach Charbonnet.

In the second quarter, Iowa responded with a 22-yard field goal by Keith Duncan, which made the score 10–3 in favor of Michigan at half-time.

Illinois finally got on the board late in the first half on a 23-yard touchdown pass from Matt Robinson to Josh Imatorbhebhe, which made the score 28–7 in favor of Michigan at half-time.

Illinois scored the only points of the third quarter on a 50-yard field goal by James McCourt and a one-yard touchdown run from Matt Robinson.

Freshman running back Zach Charbonnet had 108 rushing yards in the first half, becoming the first Wolverine to do so since Karan Higdon ran for 139 against Nebraska last season.

[48] Following its game against Illinois, Michigan traveled to Happy Valley to face the Penn State Nittany Lions.

[52] Penn State opened the scoring in the first quarter on a 17-yard touchdown pass from Sean Clifford to Pat Freiermuth.

Michigan kicker Jake Moody missed a 52-yard field goal attempt in the final minute of the half, which made the score 21–7 in favor of Penn State at half-time.

[53] After its game against Penn State, Michigan hosted the Notre Dame Fighting Irish to rekindle its long-running rivalry.

Notre Dame finally got on the board in the third quarter on a seven-yard touchdown pass from Ian Book to Cole Kmet.

Down 45–7, Notre Dame scored on a 14-yard touchdown pass from Phil Jurkovec to Javon McKinley with 3:45 remaining, and Michigan wound down the rest of the clock on its next possession.

[64] Michigan State opened the scoring in the first quarter with a one-yard touchdown pass from Brian Lewerke to Max Rosenthal.

Its next drive began on its two-yard line, and ended 12 plays and 98 yards later with a five-yard touchdown pass from Shea Patterson to Nick Eubanks.

Michigan added 10 points in the third quarter on an 18-yard touchdown pass from Patterson to Donovan Peoples-Jones and a 49-yard field goal by Nordin.

Michigan scored 18 points in the third quarter on a 27-yard field goal by Quinn Nordin, and two touchdown passes from Patterson to Collins, from 76-yards, and 19-yards, respectively.

[74] Michigan opened the scoring in the first quarter on a 22-yard touchdown run from Giles Jackson, after which Quinn Nordin's extra point missed.

Michigan responded with ten points on a seven-yard touchdown pass from Shea Patterson to Nick Eubanks, and a 36-yard field goal by Quinn Nordin to take its first lead of the game.

Quinn Nordin then kicked a Citrus Bowl record 57-yard field goal as time expired in the first half, which made the score 16–14 in favor of Michigan at half-time.