The Peoples Democratic Party lost a net total of 4 seats compared to the pre-elections situation, notably with Senate President Bukola Saraki losing in his district of Kwara Central.

[2][3] As the APC strengthened its hold on the Red Chamber, 44 seats flipped from one party to another with two dozen lawmakers losing re-election.

Notable flips included all three seats in Kwara State where Senate President and APC-turned-PDP Kwara Central Senator Bukola Saraki lost his first election amidst the Ó Tó Gẹ́ Movement against the Saraki dynasty and the state PDP.

Other major stories were the losses of other prominent senators: Binta Masi Garba (APC-Adamawa North), Victor Umeh (APGA-Anambra Central), Emmanuel Nnamdi Uba (APC[g]-Anambra South), Isah Misau (PDP[h]-Bauchi Central), Barnabas Andyar Gemade (SDP[i]-Benue North-East), George Akume (APC-Benue North-West), Suleiman Othman Hunkuyi (PDP[h]-Kaduna North), and Shehu Sani (PRP[j]-Kaduna Central).

Prior to the elections, all Rivers State APC nominees were disqualified barring two incumbent senators running for reelection from contesting.