A special election for Pennsylvania's 12th congressional district was held on May 21, 2019 following the resignation of Republican Representative Tom Marino.

A special election for the 33rd senatorial district was held on May 21 following Republican State Senator Richard Alloway's resignation from the chamber.

[4][5][6] A special election for the 41st senatorial district was held on May 21 following Republican State Senator Don White's retirement from the chamber.

[9] A special election for the 11th legislative district was held on May 21 (alongside the 2019 primary) to fill Ellis' vacancy.

Democrats selected steelworker Sam Doctor as their nominee, and Republicans nominated Marci Mustello, a scheduler for Congressman Mike Kelly.

[14][15] State Representative Vanessa Lowery Brown was re-elected in the 2018 elections, but resigned in December 2018 after being convicted of bribery.