The Rockets were led by fourth-year head coach Jason Candle and played their home games at the Glass Bowl in Toledo, Ohio.

[1] The MAC released their preseason media poll on July 23, 2019, with the Rockets predicted to finish in first place in the West Division.

Toledo's 2019 schedule will begin with four non-conference games, starting on August 31 on the road against Kentucky of the Southeastern Conference (SEC).

The Rockets will then play at home against Murray State of the Ohio Valley Conference, on the road against Colorado State of the Mountain West Conference, and finally at home against BYU, a football independent.

Toledo will not play East Division members Akron, Miami, or Ohio as part of the regular season.