The 2019 Women's State of Origin was the second State of Origin rugby league match between the New South Wales and Queensland women's teams played at North Sydney Oval on 21 June 2019.

New South Wales defeated Queensland 14–4, extending their winning streak over their rivals to four games.

[1] New South Wales halfback Maddie Studdon was awarded the Nellie Doherty Medal for Player of the Match.

[2] On 22 May 2019, North Sydney Oval was announced as the venue for the 2019 Women's State of Origin, hosting the game for the second consecutive season.

[4] New South Wales defeated Queensland 24–4 in the inaugural game at North Sydney Oval, with Blues' second-row Caitlan Johnston named Player of the Match.