The women's 100 metres hurdles at the 2019 World Athletics Championships was held at the Khalifa International Stadium in Doha, Qatar, from 5 to 6 October 2019.

[1] This event lost its defending champion when Sally Pearson retired from the sport two months earlier.

The Olympic champion Brianna McNeal disappeared quickly after twitching in her blocks before the gun and being disqualified for a false start in her heat.

In lane 9, Megan Tapper got one of the worst starts imaginable to a world championship final, stuttering to the first hurdle and hitting it.

In fifth place, Andrea Vargas improved her own Costa Rican national record for the fourth time in the 2019 season.