The women's 400 metres hurdles at the 2019 World Athletics Championships was held at the Khalifa International Stadium in Doha, Qatar, from 1 to 4 October 2019.

The 1, Muhammad had to set the world record to beat McLaughlin and win the USA Championships on a rain soaked track in Des Moines.

She was first over the first hurdle and continued to pull ahead, making up the stagger on Sage Watson to her outside before the end of the turn.

Before the end of the backstretch, Muhammad had made up another stagger on two time World Champion Zuzana Hejnová.

Through the final turn, both were well in front, Muhammad taking the hurdles about a full stride ahead of McLaughlin.