The 2020–21 season was ŠK Slovan Bratislava's 15th consecutive in the top flight of Slovak football.

Slovan were successful in their defence of the domestic double, after winning their third Slovak Super Liga title in a row and a second consecutive Slovak Cup title.

Having won the 2019–20 Slovak First Football League, Slovan contested in the UEFA Champions League, but were eliminated in the first qualifying round after a technical victory was awarded to the opponent according to the regulations related to COVID-19.

Subsequently, Slovan competed in the UEFA Europa League, but were eliminated in the second qualifying round.

As of 22 May 2021 Win Draw Loss Source: Competitions