FSV Mainz 05 participated in this season's edition of the DFB-Pokal.

The season covered the period from 1 July 2020 to 30 June 2021.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Source: Soccerway Source: DFB The league fixtures were announced on 7 August 2020.