The team began the season on 17 May 2021, in its season opener against Algeria's GS Pétroliers.
The Douanes entered the season directly as champions of the Nationale 1 and were placed in Group B.
The team advanced past the group phase as a lucky loser and qualified for the 2021 BAL Playoffs as seventh-seed.
In the quarterfinals, later to be finalist US Monastir easily eliminated Douanes.
The most remarkable players of the team were Mamadou Faye and Bara Diop, who made their debut at the international stage and would later be called up for the Senegal national basketball team.