2020–21 Al Ahly SC season

Supplier: Umbro Sponsors: WE, SAIB Bank, GLC Paints, Tiger Chips, Royal Dutch Shell Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[23] Al Ahly entered the competition for the 3rd consecutive time after winning the league and the CAF Champions League in the previous season.

Al Ahly were drawn against the winner of the tie involving AS SONIDEP from Niger and Mogadishu City from Somalia, which was won by the former.

Al Ahly were drawn in Group A alongside AS Vita Club from the Democratic Republic of the Congo, Simba from Tanzania and Al Merrikh from Sudan.

Al Ahly were drawn against Mamelodi Sundowns from South Africa.