Conference play began in December and concluded with the 2021 America East men's basketball tournament.

The America East expanded from 9 teams to 10 with the arrival of NJIT on July 1, 2020.

[1] The America East announced its preseason honors and polls on November 11, 2020.

[2] This table summarizes the head-to-head results between teams in conference play.

[3] The 2021 America East men's basketball tournament took place following the end of the conference regular season.