The 2020–21 Atlantic Coast Conference women's basketball season began with practices in November 2020, followed by the start of the 2020–21 NCAA Division I women's basketball season in November.

Prior to the start of the season, the ACC hosted two media days virtually.

[12] At the media day, both the head coaches and the Blue Ribbon Panel predicted that Louisville would be league champion.

This marked the first year that teams played a twenty-game conference schedule.

[30] Lorela Cubaj – Georgia Tech Lotta-Maj Lahtinen – Georgia Tech Dana Evans – Louisville Elissa Cunane – NC State Jakia Brown-Turner – NC State Maddy Westbeld – Notre Dame Kamilla Cardoso – Syracuse Elizabeth Kitley – Virginia Tech Aisha Sheppard – Virginia Tech Ivana Raca – Wake Forest Taylor Soule – Boston College Delicia Washington – Clemson Morgan Jones – Florida State Kayla Jones – NC State Gina Conti – Wake Forest Janelle Bailey – North Carolina Raina Perez – NC State Jayla Everett – Pittsburgh Kiara Lewis – Syracuse Tiana Mangakahia – Syracuse Gabby Elliott – Clemson Hailey Van Lith – Louisville Olivia Cochran – Louisville Deja Kelly – North Carolina Maddy Westbeld – Notre Dame Kamilla Cardoso – Syracuse Georgia Amoore – Virginia Tech Jewel Spear – Wake Forest Taylor Soule – Boston College Morgan Jones – Florida State Lorela Cubaj – Georgia Tech Dana Evans – Louisville Jakia Brown-Turner – NC State Elissa Cunane – NC State Kayla Jones – NC State Elizabeth Kitley – Virginia Tech Aisha Sheppard – Virginia Tech Ivana Raca – Wake Forest Delicia Washington – Clemson Lotta-Maj Lahtinen – Georgia Tech Maddy Westbeld – Notre Dame Kamilla Cardoso – Syracuse Gina Conti – Wake Forest Janelle Bailey – North Carolina Jayla Everett – Pittsburgh Tiana Mangakahia – Syracuse Gabby Elliott – Clemson Hailey Van Lith – Louisville Olivia Cochran – Louisville Deja Kelly – North Carolina Maddy Westbeld – Notre Dame Kamilla Cardoso – Syracuse Georgia Amoore – Virginia Tech Jewel Spear – Wake Forest The ACC had three players selected in the 2021 WNBA Draft.