[2][3][4] The season started on 2 November 2020[5] with 13 teams from the 2019–20 Azadegan League, two new teams relegated from the 2019–20 Persian Gulf Pro League: Pars Jonoubi Jam and Shahin Bushehr and three new teams promoted from the 2019–20 League 2: Chooka Talesh, Esteghlal Mollasani and Shahrdari Astara as champion, runner-up and third placed team respectively.
[6][7] Karoon Arvand Khorramshahr's 1st Division licence were taken back from Damash and then again sold to Kheybar Khorramabad.
[8] The league started on 22 November 2020 and ended on 19 July 2021.
[9][10] Fajr Sepasi Shiraz won the Azadegan League title for the first time in their history and was promoted to the Persian Gulf Pro League after an absence of eight years together with second-ranked Havadar Tehran.
Kheybar Khorramabad's Aref Rostami was the top scorer with 17 goals.