Flamengo won its second continental championship[a] after defeating Real Estelí in the final in Managua.

A total of 12 teams from 6 countries participated in the 2020–21 Basketball Champions League Americas.

[1] Because Peñarol and Aguada from Uruguay were not able to participation due to national restrictions, Minas and Obras Sanitarias were given wild cards by FIBA.

[2] Universidad de Concepción replaced Chilean champions Valdivia, who withdrew.

All games were played in the Alexis Arguello Sports Complex in the Nicaraguan capital Managua.