In addition to the domestic league, Bayer 04 Leverkusen also participated in this season's edition of the DFB-Pokal as well as the UEFA Europa League.

The season covered the period from 11 August 2020 to 30 June 2021.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[14] The group stage draw was held on 2 October 2020.