Lowest ranked teams still available were Blankenberge, Wielsbeke, Bilzerse Waltwilder and Vorselaar, all playing at the sixth level (First Provincial Division).
Lowest teams still in the competition are RAAL La Louvière, Heur-Tongeren, Lokeren-Temse and Olsa Brakel, all from the Belgian Division 2 (tier 4).
As part of containment measures taken to limit to spread of the COVID-19 disease in the second half of October, amateur clubs were not allowed to organize group training sessions until mid-December, making it very difficult for these teams to prepare for the cup matches.
Additionally, amateur clubs hosting matches without field-heating installations might lose their home advantage if weather conditions prove too challenging.
[2] With the containment measures in Belgium prolonged and amateur teams not allowed to play matches prior to 15 January unless adhering to the (expensive) professional sports protocols, an agreement was found in December with the amateur teams still in the cup to postpone all matches further, now from 9 and 10 January 2021 to the midweek of 2 to 4 February 2021.
[4] On January 19, for the same reasons, both Rupel Boom and Tessenderlo also forfeited their matches, respectively against Eupen and Genk.
The draw for the quarter-finals was made on 11 February 2021, right after the conclusion of the last match of the previous round, Union SG vs Anderlecht.
The draw for the semi-finals was made on 4 March 2021, right after the conclusion of the last match of the previous round, Standard Liège vs Club Brugge.