The Knights, led by 16th-year head coach Scott Davenport, played their home games at Freedom Hall in Louisville, Kentucky as members of the ASUN Conference.

[4] After a preseason shutdown due to the COVID-19 pandemic, the Knights ended up playing their first game at the Division I level on the road against the sixth-ranked Duke Blue Devils.

Sophomore guard Alec Pfriem came off the bench and notched the program's first ever double-double in Division I, scoring 14 points and grabbing 14 rebounds.

The Knights entered ASUN play with a 3–3 record, including losses to high-profile ACC opponents in Duke and Notre Dame.

They went on the road and swept Florida Gulf Coast in a dominant two-day set, behind the contributions of senior forward Ethan Claycomb.

Trailing by 20 with less than 19 minutes to go in the game, Bellarmine shot 84 percent from the field in the second half (21 of 25) en route to rallying past the Hatters for a 76–65 victory.

Bellarmine continued their winning streak over the next few weeks, sweeping Kennesaw State, Jacksonville, and North Alabama to get to a 10–2 record in ASUN play, which placed them at the top of the conference.