[6] 18-year-old Cameron Antwi signed his first professional contract on 3 July – a one-year deal, with the club having the option to extend for a second year.

[7] 24-year-old centre-back Marvin Ekpiteta joined on a free transfer on 8 July, having let his contract with Leyton Orient run out.

[16] Forward Nathan Delfouneso joined Bolton Wanderers, managed by his former Seasiders teammate Ian Evatt, the same day.

On 8 August, Blackpool made the short trip down the coast to play Southport to kick-off their pre-season campaign — their first fixture in 151 days.

Grant Ward opened the scoring in the first half, before further second-half strikes from Sullay Kaikai and debutant pair Keshi Anderson and Jerry Yates sealed a 4–0 victory for Neil Critchley's side.

[29] Blackpool's season opened with an EFL Cup first-round tie with Stoke City at the Britannia Stadium on 29 August.

[31] September began with another new signing, with forward Bez Lubala joining, for an undisclosed fee, from Crawley Town.

[35] The arrival of left-back Demetri Mitchell on 4 September made it four transactions in as many days, and brought the Seasiders' number of incomings for the season to eleven.

[44] The following day, Blackpool drew 1–1 with Accrington Stanley in the EFL Trophy, but they missed out on a bonus point by losing in the subsequent penalty shootout.

[48] Inbound were forward Ben Woodburn, on loan from Liverpool,[49] and Australian midfielder Kenny Dougall, on a free transfer.

[54] Five days later, the Seasiders made it into the hat for the second-round draw of the FA Cup with a 3–0 win at Eastbourne Borough, the biggest game in the hosts' history.

[55][56] Blackpool made it four consecutive victories, and their fifth in six,[57] with a 3–0 scoreline at home to Leeds United Under-21s in the EFL Trophy on 11 November.

[58] After a ten-day break, Blackpool travelled to Peterborough United, and returned with all three points in a 2–1 victory, extending their winning streak to five.

[60][61] Doncaster Rovers brought Blackpool's winning run to an end on 24 November, coming from 0–2 down with three second-half goals.

Jerry Yates had opened the scoring for the visitors from the penalty spot, making himself the club's top goal scorer, with five in all competitions, in the process.

They made it eight wins from their last nine matches on 5 December, with a 1–0 edging of Fylde Coast rivals Fleetwood Town at Highbury Stadium.

[69] Goalkpeeper Sam Walker joined on an emergency seven-day loan on 23 December, as cover for Chris Maxwell, who tested positive for COVID-19.

[72] Seven days later, Blackpool secured a place in the fourth round of the FA Cup at the expense of former Seasiders manager Sam Allardyce's West Bromwich Albion.

The goals came from Marvin Ekpiteta, Jerry Yates, Matty Virtue and two from Everton loanee Ellis Simms.

[76] On 1 February, transfer-deadline day, Blackpool loaned out defender Teddy Howe to Scunthorpe United and forward Oliver Sarkic to Mansfield Town.

Jerry Yates scored his 11th goal of the campaign on 82 minutes to give the visitors the three points, which lifted them up to 13th place in the table.

On 20 March, Blackpool recorded a 2–0 victory at Oxford United, with the goals coming from Kenny Dougall (his first for the club) and Dan Ballard.

Blackpool won 3–1, with two goals by Jerry Yates and one from Luke Garbutt, extending their unbeaten run to ten games, and climbed into the top six for the first time.

Ryan Hardie, who left Blackpool for the Pilgrims earlier in the season, put the visitors ahead on 12 minutes.

Jerry Yates put Blackpool ahead from the penalty spot on 64 minutes, but Joe Edwards levelled matters again in injury time.

The Seasiders won 4–1, with two goals from Jerry Yates (on 5' and 20', bringing his season total to 20 in all competitions) and one each from Sullay Kaikai (30') and Elliot Embleton (61'), his first for the club.

Blackpool won the first leg of the play-off semi-finals, at Oxford United on 18 May, 3–0, with a goal from Ollie Turton and a double from Ellis Simms.

)[94] Released were Liam Feeney, Alex Fojticek, Sullay Kaikai, Jack Sims and Adi Yussuf.

[97][98] On 8 June, Blackpool made three new signings, all of whom officially joined on 1 July: defender Reece James,[99] goalkeeper Daniel Grimshaw[100] and Northern Ireland international striker Shayne Lavery.

[112] The third-round draw was made on 30 November, with Premier League and EFL Championship clubs all entering the competition.