[1] The Bruins entered the season as defending Presidents' Trophy and Atlantic Division champions.
On December 20, 2020, the league temporarily realigned into four divisions with no conferences due to the COVID-19 pandemic and the ongoing closure of the Canada–United States border.
On March 25, spectators were allowed back into the TD Garden with a limited capacity of 2,200.
This was the first time fans were in attendance at a Bruins home game since March 7 of the previous year.
The rescheduled draft was held October 6–7, 2020 virtually via Video conference call from the NHL Network studio in Secaucus, New Jersey.