In a bid to enable increased attendances amid COVID-19 restrictions and social distancing measures, Bristol City announced they were moving from the 1,500 capacity Stoke Gifford Stadium in Filton which had been purpose-built by the club in 2011 ahead of the first WSL season, to Twerton Park, an 8,800 capacity stadium home to Bath City FC.

[1][2] On 2 September, Jasmine Matthews was named as captain following the departure of Loren Dykes.

[3] On 15 January 2021, Tanya Oxtoby temporarily stepped down as head coach to take maternity leave.

Two-time WSL winner Matt Beard, who had left West Ham United in November, was appointed caretaker manager until the end of the season.

[4] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.