The 2020–21 Buffalo Bulls men's basketball team represented the University at Buffalo in the 2020–21 NCAA Division I men's basketball season.

The Bulls, led by second-year head coach Jim Whitesell, played their home games at Alumni Arena in Amherst, New York as members of the Mid-American Conference.

Starting this season, the MAC announced the removal of divisions.

They defeated Miami (OH) and Akron to advance to the championship game of the MAC tournament where they lost to Ohio.

They were upset in the first round of the MAC tournament by Miami (OH).