[1] On December 20, 2020, the league temporarily realigned into four divisions with no conferences due to the COVID-19 pandemic and the ongoing closure of the Canada–United States border.
With an 18th consecutive loss on March 29, 2021, the Sabres equalled the NHL record for the longest losing streak in a season, tied with the 2003–04 Pittsburgh Penguins.
[4] On November 16, 2020, the NHL introduced Adidas "Reverse Retro" jerseys for all 31 teams, which feature throwback uniforms with a modern twist.
Below are the Buffalo Sabres' selections at the 2020 NHL Entry Draft, which was originally scheduled for June 26–27, 2020 at the Bell Center in Montreal, but was postponed on March 25, 2020, due to the COVID-19 pandemic.
It was held October 6–7, 2020 virtually via Video conference call from the NHL Network studio in Secaucus, New Jersey.