Al Ahly successfully defended their title and defeated Kaizer Chiefs 3–0 in the final, which was played at Stade Mohammed V in Casablanca, Morocco, winning their record-extending tenth and second consecutive title.

[2] As a result, theoretically a maximum of 68 teams could enter the tournament – although this level has never been reached.

The criteria for points are the following:[3][4][5] The points are multiplied by a coefficient according to the year as follows: Due to the COVID-19 pandemic, associations may abandon their domestic competitions and select the representatives in CAF club competitions.

[43] The draw for the qualifying rounds was held on 9 November 2020 at the CAF headquarters in Cairo, Egypt.

Notes: The draw for the group stage was held on 8 January 2021, 12:30 GMT (14:30 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.