The 2020–21 CAF Confederation Cup group stage started on 10 March and ended on 28 April 2021.
[2] The draw for the group stage was held on 22 February 2021, 13:00 GMT (15:00 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.
[3] The 16 teams, which consist of the 15 winners of the play-off round of qualifying and defending champions RS Berkane, were drawn into four groups of four.
The winners and runners-up of each group will advance to the quarter-finals of the knockout stage.
During the Islamic holy month Ramadan (12 April – 12 May), CAF gave clubs the option to play their home matches late in the day to avoid having large number of players fasting during matches.