The team that scores more goals on aggregate over the two legs advances to the next round.
If away goals are also equal, then extra time is not played and the winners are decided by a penalty shoot-out.
In the final, which is played as a single match, if the score is level at the end of normal time, extra time won't also be played and the winners will be decided by a penalty shoot-out.
The bracket of the knockout stage is determined as follows:[1] The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 30 April 2021, 14:00 CAT (UTC+2), at the CAF headquarters in Cairo, Egypt.
The final was played on 10 July 2021 at Stade de l'Amitié, Cotonou.