The 2020–21 CAF Confederation Cup qualifying rounds were played from 27 November 2020 to 21 February 2021.
[1][2] A total of 67 teams are competing in the qualifying rounds to decide the 16 places in the group stage of the 2020–21 CAF Confederation Cup.
[3] The draw for the qualifying rounds was held on 9 November 2020 at the CAF headquarters in Cairo, Egypt.
[4][5] The entry round of the 51 teams entered into the draw was determined by their performances in the CAF competitions for the previous five seasons (CAF 5-year ranking points shown in parentheses).
In the qualifying rounds, each tie will be played on a home-and-away two-legged basis.
If the aggregate score is tied after the second leg, the away goals rule will be applied, and if still tied, extra time will not be played, and the penalty shoot-out will be used to determine the winner (Regulations III.
[2] The bracket of the draw was announced by the CAF on 9 November 2020.
TAS Casablanca won on walkover after GAMTEL withdrew from the second leg in Morocco citing financial constraints.
Namungo won on walkover after Al Rabita were disqualified by CAF due to violation of regulations from the club and the South Sudan Football Association.
ES Sétif won on walkover after Renaissance were disqualified by CAF for failing to appear for the first leg in N'Djamena.
Orlando Pirates won on walkover after Sagrada Esperança withdrew from the second leg in South Africa citing health concerns caused due to the new COVID-19 variant.
The draw for the play-off round was held on 8 January 2021, 12:00 GMT (14:00 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.
The 15 winners of the play-off round will advance to the group stage to join RS Berkane, who advanced directly to the group stage as the winners of the first round with the best CAF 5-year ranking following Gazelle withdrawal from the competition after being transferred from the Champions League.