The 2020–21 CEV Challenge Cup was the 41st edition of the CEV Challenge Cup tournament.

33 teams from 22 countries were participating in the competition.

[1] Qualification Phase (Knock-out with Home and Away Matches): 1st Round (if needed) → 2nd Round Main Phase (Knock-out with Home and Away Matches): 1/16 Finals → 1/8 Finals→1/4 Finals Final Phase (Knock-out with Home and Away Matches): Semi-Finals → Final Aggregate score is counted as follows: 3 points for 3–0 or 3–1 wins, 2 points for 3–2 win, 1 point for 2–3 loss.

In case the teams are tied after two legs, a Golden Set is played immediately at the completion of the second leg.