The 2020–21 CEV Champions League was the highest level of European club volleyball in the 2020–21 season and the 61st edition.

In case of a tie in the number of matches won by two or more teams, their ranking is based on the following criteria:[4] A knockout format where the 8 qualified teams are each draw into the quarter-finals with the round winners advancing to the next rounds (semifinals and final).

[4] A single match between the winners of the semifinals in a neutral venue decides the tournament champion.

[3] Drawing of lots for the league round was held on 21 August 2020 in Luxembourg City.

[1][6] Vakıfbank Istanbul (Turkey 1) Imoco Volley Conegliano (Italy 1) Dinamo-Ak Bars (Russia 1) Eczacıbaşı VitrA Istanbul (Turkey 2) Unet E-Work Busto Arsizio (Italy 2) Chemik Police (Poland 1) ASPTT Mulhouse (France 1) Lokomotiv Kaliningrad (Russia 2) Developres SkyRes Rzeszów (Poland 2) Nantes VB (France 2) SSC Palmberg Schwerin (Germany 1) Maritza Plovdiv (Bulgaria 1) VK UP Olomouc (Czech 1) LP Salo (Finland 1) Fenerbahçe SK Istanbul (Turkey 3) Igor Gorgonzola Novara (Italy 3) Uralochka-NTMK Ekaterinburg (Russia 3) Winner from Qualification Winner from Qualification Winner from Qualification After drawing of lots, LP Salo[7] and Uralochka-NTMK Ekaterinburg[8] announced their withdrawal from the competition.