The 2020–21 Cal Poly Mustangs men's basketball team represented California Polytechnic State University in the 2020–21 NCAA Division I men's basketball season.

The Mustangs, led by second-year head coach John Smith, played their home games at the Mott Athletics Center in San Luis Obispo, California as members of the Big West Conference.

The Mustangs finished the 2019–20 season 7–23, 4–12 in Big West play to finish in last place.

They failed to qualify for the Big West tournament (although the Big West tournament was ultimately cancelled due to the COVID-19 pandemic).

Roster Last update: November 25, 2020 Source[1]