The 2020–21 Campionato Sammarinese di Calcio was the 36th edition of league competition in San Marino, in which the country's top 15 amateur football teams participate.
[1] The previous season was abandoned due to the COVID-19 pandemic in San Marino.
[4] After a delay due to the COVID-19 pandemic, the league restarted on 24 February 2021.
[7] When a match ends in a draw, the team with the better regular season position advances.
Folgore qualified for the 2021–22 UEFA Champions League preliminary round.